High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks
High-performance microbial opsins for spatially and temporally precise perturbations of large neuronal networks In brief: Using structure-guided design, the authors develop second-generation ChroME-based cation channel rhodopsins that exhibit extremely high potency while preserving fast kinetics, thereby expanding the optogenetic toolbox. ChroME2.0 opsins permit spatially and temporally precise two-photon holographic neural control at unprecedented scales, a […]
