Meadowlark Optics Has Pivotal Role in Fusion Research
The Beginning Back in 1952, the first useful demonstration of nuclear fusion was carried out. It was for vastly different reasons than those celebrated most recently, although one might say that was when interest in atomic science for practical applications really blew up (pun intended.) Physicists have been seeking fusion as a viable energy source ever since, with […]
Holographic Optical Tweezing (Hot) Application Note
Summary Holographic optical tweezing leverages tightly focused laser beams to precisely manipulate objects in three-dimensional space, making it a powerful tool for fundamental physics, biological research, and cold atom trapping. By utilizing a spatial light modulator (SLM) to modulate the phase of an incident laser beam, this technique generates a 3D volume of focal points […]
General Microscopy Application Note
Summary Advancements in microscopy imaging are addressing key challenges such as spherical aberration correction in 3D imaging, motion artifact reduction, and the development of new imaging modalities. Spatial light modulators (SLMs) play a crucial role in enhancing traditional microscopy by dynamically controlling wavefronts to optimize image quality. By integrating SLMs, researchers can correct optical distortions, […]
Psf Engineering Application Note
Welcome to Meadowlark Optics, Photonics Media Reader Browse our online products below, or Visit Our Online Store to Filter and Sort. Read more Polarimeter Compact No moving parts Broad wavelength range Versatile Configuration User-Friendly Operation High Sensitivity Our NEW user-friendly Liquid Crystal Stokes vector Polarimeter (PMI-2000) provides high accuracy and reliability in an easy-to-use… Read […]
Fiber-Based Optical Manipulation Application Note
Summary Fiber optic communications are now being integrated with spatial light modulators (SLMs) for deep tissue imaging, overcoming optical scattering limitations. Multi-mode fibers (MMFs) are particularly advantageous due to their small form factor, minimizing tissue damage during biomedical imaging applications. However, a key challenge in MMF-based imaging is that fiber manipulation introduces phase errors, which […]
Volumetric Imaging Application Note
Summary In order to understand biological functions at a system level it is necessary to image interconnectivity of processes in real time. This is particularly relevant in neuroscience, where the BRAIN initiative is funding research to understand how the brain functions, and how that function is altered by disease. This requires imaging with single cell […]
Imaging In Scattering Or Turbid Media
Summary Adaptive optics (AO) was originally developed to correct aberrations caused by atmospheric turbulence in monochromatic imaging and laser communication systems. By integrating a liquid crystal spatial light modulator (SLM), wavefront distortions can be precisely corrected, restoring diffraction-limited image quality. Recent advancements have extended these techniques to biological imaging, where scattering and turbidity pose challenges […]
Sensorless Adaptive Optics for Multimode Optical Fibre Endo-Microscopy
Summary Diffraction-limited one-photon fluorescence microscopy of deep brain regions in vivo has recently been demonstrated through multimode optical fibres (MMF) [1,2], a promising approach in adaptive optics microscopy and biological imaging. An essential component of such microscopy adaptive optics systems is a spatial light modulator, a widely used adaptive optics component. Wavefront shaping is indeed […]
An open source three-mirror laser scanning holographic two-photon lithography system.
Summary Two-photon polymerization (TPP) is a leading technique for fabricating 2D and 3D nanostructures with sub-diffraction-limit features. This study introduces an open-hardware, open-software holographic multibeam TPP system featuring a phase-only spatial light modulator (SLM) and a three-mirror scan head. The novel three-reflective surface design—with two mirrors scanning along the same axis—resolves virtual conjugation loss in […]
Revealing architectural order with quantitative label-free imaging and deep learning
Summary We report quantitative label-free imaging with phase and polarization (QLIPP) for simultaneous measurement of density, anisotropy, and orientation of structures in unlabeled live cells and tissue slices, using advanced image processing techniques. We combine QLIPP with deep neural networks and machine learning models to predict fluorescence images of diverse cell and tissue structures, enhancing […]
